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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2022; 10(24): 8436-8442
Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8436
Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8436
NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease?
Mao-Lin Zhang, Zhi-Ming Qin, Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China
Long-Qing Ran, Meng-Jun Wu, Department of Anesthesia, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610019, China
Qin-Chen Jia, Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China
Yong G Peng, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, United States
Author contributions: Zhang ML and Ran LQ contributed equally to this work, They edited the article together; Wu MJ provided writing guidance for this paper; Jia QC collected and organized the articles; Yong GP polished the language of the article; Qin ZM determined the propositional direction of the article; all authors have read and approved the final manuscript.
Conflict-of-interest statement: There is no conflict of interest in this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this worκ non-commercially, and license their derivative worκs on different terms, provided the original worκ is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Ming Qin, MS, Assistant Professor, Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, China, Chongqing 400042, China. Qzm201596@163.com
Received: April 1, 2022
Peer-review started: April 1, 2022
First decision: June 7, 2022
Revised: June 16, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 26, 2022
Peer-review started: April 1, 2022
First decision: June 7, 2022
Revised: June 16, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 26, 2022
Core Tip
Core Tip: Gastroesophageal reflux disease (GERD) is one of the most common chronic diseases. Current treatments, including drugs and surgery, have significant side effects and some patients do not respond to treatment. This article reviews the pathogenesis of GERD, especially the relationship between the NF-κB pathway and GERD. We also assessed the latest studies on the effects of drugs inhibiting the NF-κB pathway in GERD, providing new possibilities for the treatment of GERD.