Role of micronutrients in Alzheimer's disease: Review of available evidence

doi:10.12998/wjcc.v10.i22.7631

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World Journal of Clinical Cases

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World J Clin Cases. Aug 6, 2022; 10(22): 7631-7641
Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7631

Role of micronutrients in Alzheimer's disease: Review of available evidence

Hong-Xin Fei, Chao-Fan Qian, Xiang-Mei Wu, Yu-Hua Wei, Jin-Yu Huang, Li-Hua Wei

Hong-Xin Fei, Chao-Fan Qian, Xiang-Mei Wu, Yu-Hua Wei, Li-Hua Wei, Department of Pathology, Guangxi University of Science and Technology, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China

Jin-Yu Huang, Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China

Author contributions: Fei HX, Huang JY, and Wei LH had the idea for the article; Fei HX wrote the initial paper; Huang JY and Wei LH critically revised the paper; all authors performed the literature search and data analysis, read and approved the final manuscript.

Supported by Guangxi Zhuang Autonomous Region Natural Science Fund, No. 2020GXNSFAA297001; Guangxi Zhuang Autonomous Region Liuzhou Science and Technology Program Fund, No. 2020NBAA0805; Guangxi University of Technology, No. 20Z06; and Jiangxi Social Science Research and Planning Fund, No. 19JY34.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jin-Yu Huang, MD, Director, Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, No. 124 Yuejin Road, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China. lilin2169@163.com

Received: January 26, 2022
Peer-review started: January 26, 2022
First decision: March 23, 2022
Revised: April 29, 2022
Accepted: June 21, 2022
Article in press: June 21, 2022
Published online: August 6, 2022

Core Tip

Core Tip: Significant advances have been made in characterizing the relationship between Alzheimer's disease (AD) and micronutrients copper, zinc, iron, selenium, silicon, manganese, and arsenic. This study provides a new perspective and direction for future scientific research, development of new drugs, and routine preventive measures against AD.