Zeng YF, Dai YZ, Chen M. Mammary-type myofibroblastoma with infarction and atypical mitosis-a potential diagnostic pitfall: A case report. World J Clin Cases 2022; 10(16): 5343-5351 [PMID: 35812659 DOI: 10.12998/wjcc.v10.i16.5343]
Corresponding Author of This Article
Yuan-Feng Zeng, Doctor, PhD, Chief Doctor, Department of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 92 Aiguo Road, Donghu District, Nanchang 330006, Jiangxi Province, China. zyf760928@163.com
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2022; 10(16): 5343-5351 Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5343
Mammary-type myofibroblastoma with infarction and atypical mitosis-a potential diagnostic pitfall: A case report
Yuan-Feng Zeng, Yan-Zhi Dai, Min Chen
Yuan-Feng Zeng, Yan-Zhi Dai, Min Chen, Department of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi Province, China
Author contributions: Zeng YF checked the section reading, made the final pathological diagnosis, reviewed the literature, and wrote the manuscript; Dai YZ collated the clinical data, prepared histological sections, and performed immunohistochemical and fluorescence in situ hybridization; Chen M prepared tissue samples and made preliminary diagnosis; and all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Feng Zeng, Doctor, PhD, Chief Doctor, Department of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 92 Aiguo Road, Donghu District, Nanchang 330006, Jiangxi Province, China. zyf760928@163.com
Received: July 18, 2021 Peer-review started: July 18, 2021 First decision: October 16, 2021 Revised: November 4, 2021 Accepted: April 26, 2022 Article in press: April 26, 2022 Published online: June 6, 2022
Core Tip
Core Tip: Mammary-type myofibroblastoma (MTMF) is a rare extra-mammary soft tissue tumor with myofibroblast differentiation. Since 2001, more than 160 cases have been reported in the literature. Almost all reports have identified MTMF as a benign tumor except for three cases of recurrence. Here, we report a case of MTMF, which mimicked some malignant features, such as infarction, atypical mitosis, infiltrative growth, and cytologic atypia. Although infiltrative growth and cytological atypia have been reported in previous cases, there are no reports of infarction and atypical mitosis in MTMF, and this is the first report that these pseudo-malignant features appear simultaneously in the same case. Taken together, these characteristics pose a diagnostic pitfall that must be avoided. The purpose of this report is to alert pathologists if they encounter a tumor with these pseudo-malignant features and myofibroblastic differentiation, they must not forget that they need to rule out the diagnosis of MTMF first.
