Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2022; 10(13): 4242-4248
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4242
Primary isolated central nervous system acute lymphoblastic leukemia with BCR-ABL1 rearrangement: A case report
Yan Chen, Quan-Yi Lu, Jing-Yuan Lu, Xiu-Li Hong
Yan Chen, Quan-Yi Lu, Jing-Yuan Lu, Xiu-Li Hong, Department of Hematology, Zhongshan Hospital of Xiamen University, Xiamen 361000, Fujian Province, China
Author contributions: Lu QY designed the research; Lu JY and Hong XL performed the research; Chen Y analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Supported by the Science and Technology Plan Guide Project of Fujian Province, No. 2019D009.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors declared that they have no conflicts of interest regarding this work.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Quan-Yi Lu, MD, Chief Doctor, Department of Hematology, Zhongshan Hospital of Xiamen University, No. 209 Hubin South Road, Xiamen 361000, Fujian Province, China. luquanyi@xmu.edu.cn
Received: October 21, 2021
Peer-review started: October 21, 2021
First decision: December 17, 2021
Revised: January 4, 2022
Accepted: March 15, 2022
Article in press: March 15, 2022
Published online: May 6, 2022
Core Tip

Core Tip: We report a rare newly diagnosed case in a female patient with BCR-ABL-positive leukemia cells primarily located in the arachnoid surface and the subarachnoid space, clinically manifesting as leukemic meningitis, without blood and bone marrow involvement. Given the rarity of this specific presentation of B cell-acute lymphocytic leukemia, the diagnosis and treatment approach are challenging.