Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2022; 10(11): 3587-3592
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3587
Ultrasound-guided local ethanol injection for fertility-preserving cervical pregnancy accompanied by fetal heartbeat: Two case reports
Toshiyuki Kakinuma, Kaoru Kakinuma, Yoshio Matsuda, Michitaka Ohwada, Kaoru Yanagida, Hirotsune Kaijima
Toshiyuki Kakinuma, Kaoru Kakinuma, Yoshio Matsuda, Michitaka Ohwada, Kaoru Yanagida, Department of Obstetrics and Gynecology, International University of Health and Welfare Hospital, Nasushiobara 329-2763, Japan
Hirotsune Kaijima, Minatomirai Yume Clinic, Yokohama 220-0012, Japan
Author contributions: Kakinuma T designed the research study and wrote the manuscript; Kakinuma T, Kakinuma K, Ohwada M and Yanagida K performed the research; Matsuda Y and Kaijima H provided help and advice on the study protocol; All authors read and approved the final manuscript.
Informed consent statement: The study was approved by the Ethics Committee of the International University of Health and Welfare Hospital (Approval date: July 21, 2021; Approval number 21-B-8). The patients provided consent after receiving written and verbal explanation of the study protocol.
Conflict-of-interest statement: The authors declare no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Toshiyuki Kakinuma, MD, PhD, Professor, Department of Obstetrics and Gynecology, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara 329-2763, Japan. kakinuma@iuhw.ac.jp
Received: December 1, 2021
Peer-review started: December 1, 2021
First decision: January 22, 2022
Revised: February 7, 2022
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Core Tip

Core Tip: We describe the use of transvaginal ultrasound-guided local injection of absolute ethanol as a new treatment method for cervical pregnancy that preserves fertility. In both cases, the patients had developed cervical pregnancy through assisted reproductive technology and sought fertility-preserving treatment. A local injection of absolute ethanol allowed resumption of menstruation 2 mo after treatment and early resumption of infertility treatment without any complications. We suggest that local injection of absolute ethanol for cervical pregnancy could be a safe and effective new treatment method.