Published online Nov 6, 2020. doi: 10.12998/wjcc.v8.i21.5139
Peer-review started: June 28, 2020
First decision: July 24, 2020
Revised: August 4, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: November 6, 2020
Endoscopic ultrasound-guided needle aspiration technology is applied to the diagnosis of lung cancer, which exempts many patients from undergoing more traumatic examinations. It has been gradually promoted in clinical practice. Whether the limited puncture tissue can be used for pathological diagnosis, molecular diagnosis, etc. and obtain reliable results, is the question we wanted to clarify in order to help us understand whether the technology can efficiently assist clinical diagnosis and treatment.
To evaluate the value of endoscopic ultrasound-guided needle aspiration in the diagnosis of lung cancer.
Through retrospective research to understand the success rate of molecular diagnosis of non-small cell lung carcinoma with puncture specimens. To evaluate the reliability of the diagnosis results through follow-up of clinical treatment effects.
According to the location of the patient’s lesion, we choose to use endoscopic ultrasonography-guided fine-needle aspiration or endobronchial ultrasound-guided transbronchial needle aspiration. Due to the different accessibility of lung and mediastinal lesions, the two puncture methods are considered to be complementary. We used Sanger sequencing for mutation analysis of EGFR, KRAS, MET and HER2. This is not the most advanced detection method, but the test results are reliable. Moreover, it does not require high costs, so more patients can benefit from it.
In this study, 93.9% of the punctured tissues met the molecular test standards. The test results were in line with the mutation frequency of the patient population. The patients who received targeted therapy according to the test results responded well. These results add evidence to support the application value of this technology in diagnosis of non-small cell lung carcinoma. However, this study lacks comparison data between this technique and other methods, so it cannot prove that it is the first choice for clinical diagnosis.
The two puncture methods are considered to be complementary. They can puncture almost all the mediastinal lymph nodes. This technique obtains diseased tissue under minimally invasive conditions, thus reducing unnecessary surgical intervention. The diagnosis results are reliable and can effectively guide clinical treatment.
Advantages and problems of endoscopic ultrasound in diagnosis and treatment of lung cancer and gastrointestinal tumors.