Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5678
Peer-review started: May 19, 2023
First decision: June 1, 2023
Revised: June 2, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 26, 2023
Hypertension is a common chronic disease that affects many people worldwide. Hypertension can lead to various complications, including prethrombotic state and thrombotic diseases, which pose a significant risk to patients' health.
The study collected data from patients with different grades of hypertension and compared them with a control group. The results showed that certain indicators, such as high-sensitivity C-reactive protein (hs-CRP), thrombomodulin (TM), hematocrit (Hct), erythrocyte sedimentation rate (ESR), P-selectin on platelet surface (CD62P), platelet (PLT), activated partial thromboplastin time (APTT), prothrombin (PT), plasma thrombin time (TT), and fibrinogen (FIB), were associated with PH progression, and their expression levels differed among the groups. High expression of some indicators, such as hs-CRP, TM, Hct, ESR, CD62P, and fibrinogen, and low expression of others, such as PLT, APTT, PT, and TT, were identified as risk factors for PH. The findings suggest that targeted interventions based on these indicators' expression levels could help control the progression of PH and reduce the risk of developing a prethrombotic state.
The research objectives were to investigate the relationship between these indicators and the progression of PH and identify risk factors for the development of prethrombotic state in hypertensive patients.
This study retrospectively collected general data from patients with primary hypertension. The patients were divided into three groups based on their hypertension grade, and a control group was included. Relevant indicators of prethrombotic state were compared among the groups, including inflammation-related indicators, hemorheology-related indicators, vascular endothelial injury-related indicators, platelet-related indicators, and coagulation function-related indicators. Multivariate logistic regression models and receiver operating characteristic curve analyses were used to analyze the relationship between these indicators and PH progression. Linear correlation analysis was also performed.
The study results showed that certain indicators, including hs-CRP, TM, Hct, ESR, CD62P, PLT, APTT, PT, TT, and FIB, were associated with PH progression. The expressions of these indicators varied among hypertensive patients with different grades of hypertension and the control group. High expression of hs-CRP, TM, Hct, ESR, CD62P, and FIB, and low expression of PLT, APTT, PT, and TT, were identified as risk factors for PH.
This study identified the relevant indicators associated with prethrombotic state in patients with primary hypertension. The expressions of these indicators varied among hypertensive patients with different grades of hypertension and the control group. High expression of certain indicators and low expression of others were identified as risk factors for PH progression and the development of a prethrombotic state. The study findings suggest that monitoring and controlling the expression levels of these indicators could help prevent and treat hypertensive thrombotic diseases. The results provide a laboratory basis for clinical prevention and control of hypertensive thrombotic diseases, offering valuable insights into the mechanisms underlying the development of thrombotic events in hypertensive patients.
The findings of this study could pave the way for future research to investigate the mechanisms underlying the relationship between prethrombotic state and hypertension progression. Further studies could explore the efficacy of targeted interventions based on these indicators' expression levels to prevent and treat hypertensive thrombotic diseases. Additionally, future research could investigate the potential of these indicators as biomarkers for monitoring the progression of PH and predicting the development of thrombotic events in hypertensive patients. The study's results provide valuable insights into the pathophysiology of hypertensive thrombotic diseases and offer a basis for the development of personalized and effective prevention and treatment strategies for patients with PH.