Song Y, Wang H, Tao YH. Risk factors and optimal predictive scoring system of mortality for children with acute paraquat poisoning. World J Clin Cases 2022; 10(15): 4799-4809 [PMID: 35801032 DOI: 10.12998/wjcc.v10.i15.4799]
Corresponding Author of This Article
Yu-Hong Tao, PhD, Chief Doctor, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 Renmin Road, Chengdu 610041, Sichuan Province, China. hxtyh@sina.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2022; 10(15): 4799-4809 Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.4799
Risk factors and optimal predictive scoring system of mortality for children with acute paraquat poisoning
Yue Song, Hua Wang, Yu-Hong Tao
Yue Song, Hua Wang, Yu-Hong Tao, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yue Song, Hua Wang, Yu-Hong Tao, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Song Y and Wang H designed the study, made the review, and wrote the manuscript; Song Y, Wang H, and Tao YH made the literature search, made table, and reviewed the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of the West China Second University Hospital, Sichuan University. Approval No: 2020(004).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Hong Tao, PhD, Chief Doctor, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 Renmin Road, Chengdu 610041, Sichuan Province, China. hxtyh@sina.com
Received: November 6, 2021 Peer-review started: November 6, 2021 First decision: December 27, 2021 Revised: December 31, 2021 Accepted: March 25, 2022 Article in press: March 25, 2022 Published online: May 26, 2022
ARTICLE HIGHLIGHTS
Research background
The mortality rate in children with acute paraquat intoxication (APP) was 14.38%-63.6%, the early and accurate prediction of mortality is very important in clinical decision-making for children with APP.
Research motivation
The mortality rate in children with APP was high. The early prediction of mortality is important in clinical decision-making for patients with APP. Therefore, our aim is to optimize a predictive scoring system for mortality in children with APP.
Research objectives
Our aim is to optimize a predictive scoring system for mortality in children with APP, and help doctors to make clinical decisions.
Research methods
We compared the clinical characteristics between the two groups and analyzed the independent prognostic risk factors. The survival rates were assessed using kaplan-meier survival analysis. The best scoring system was established by using the area under the receiver operating characteristic curve analysis.
Research results
Alanine aminotransferase (ALT) and pediatric critical illness score (PCIS) were independent prognostic risk factors for children with APP. The survival rate of children classified as extremely critical patients was significantly lower than that of children classified as critical or noncritical patients. The sensitivity and specificity of ALT combined with PCIS were high.
Research conclusions
ALT and PCIS were independent prognostic risk factors for children with APP. ALT combined with PCIS is an optimal predictive mortality scoring system for children with APP.
Research perspectives
The results of this study need to be further verified by large-sample and multicenter research.
