Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2015; 3(4): 389-392
Published online Apr 16, 2015. doi: 10.12998/wjcc.v3.i4.389
Unusual histological variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation
Smita Shete, Saroj Bolde, Gopal Pandit, Pushkar Matkari, Sachin B Ingle
Smita Shete, Saroj Bolde, Gopal Pandit, Pushkar Matkari, Department of Pathology, Dr. Vaishampayan Memorial Government Medical College, Solapur, Maharashtra 4132512, India
Sachin B Ingle, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India
Author contributions: Shete S, Bolde S, Pandit G and Matkari P diagnosed the case and prepared the first draft of manuscript; Ingle SB prepared the final draft of manuscript and revised the intellectual content and gave final approval of manuscript.
Ethics approval: According to our ethical committee, as it’s a single case report on tissue histopathology (not on live patient) no need of approval as there is no question of unethical practice.
Informed consent: As we are presenting only histopathological diagnosis, not doing any experiments on the live object, we have done only diagnosis in pathology lab so no question of disclosing the patients details name /his consent that is also not indicated.
Conflict-of-interest: None is to be declared that is clearly mentioned before submission and also in the copyright form.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sachin B Ingle, Professor (Secretary Research and Development, MIMSR Medical College, Latur), Department of Pathology, MIMSR Medical College, Ambajogai Road, vishwanathpuram, Latur, Maharashtra 4132512, India. dr.sachiningle@gmail.com
Telephone: +91-2382-227424 Fax: +91-2382-228939
Received: October 21, 2014
Peer-review started: October 21, 2014
First decision: December 12, 2014
Revised: January 4, 2015
Accepted: February 4, 2015
Article in press: February 9, 2015
Published online: April 16, 2015
Abstract

Malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic differentiation is called as malignant triton tumor (MTT). It is highly aggressive soft tissue tumor with higher local recurrence rate. MTT has poor prognosis than MPNST. MTT seems to be more aggressive in patients with neurofibromatosis (NF-1). We herein, reporting an interesting case of 55 years male with multiple neurofibromas all over the body since 30 years and multiple café-au-lait spots, diagnosed as NF-1. Since 6 years, he had an enlarged mass in left thigh. Wide excision of mass was done. On histopathological examination revealed the diagnosis of MTT and diagnosis of which was confirmed on immunohistochemistry.

Keywords: Malignant triton tumor, Neurofibromatosis-1, Desmin, S-100 protein

Core tip: Meticulous histopathological examination along with immunohistochemistry is the mainstay to arrive at such rare histological diagnosis. The surgical pathologist should keep in mind such rare entity while dealing with such kind of patients.