Marquez-Batalla S, Fraile-Villarejo E, Belhassen-García M, Gutierrez-Zubiaurre N, Cordero-Sánchez M. Disseminated infection due to Mycobacterium bovis after intravesical BCG instillation. World J Clin Cases 2014; 2(7): 301-303 [PMID: 25032208 DOI: 10.12998/wjcc.v2.i7.301]
Corresponding Author of This Article
Moncef Belhassen-García, MD, PhD, Servicio de Medicina Interna, Seccion de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de investigacion Biomedica de Salamanca (IBSAL), Universidad de Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain. mbelhassen@hotmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2014; 2(7): 301-303 Published online Jul 16, 2014. doi: 10.12998/wjcc.v2.i7.301
Disseminated infection due to Mycobacterium bovis after intravesical BCG instillation
Sara Marquez-Batalla, Esther Fraile-Villarejo, Moncef Belhassen-García, Nieves Gutierrez-Zubiaurre, Miguel Cordero-Sánchez
Sara Marquez-Batalla, Esther Fraile-Villarejo, Servicio de Medicina Interna (CAUSA), IBSAL, Universidad de Salamanca, 37007 Salamanca, Spain
Moncef Belhassen-García, Miguel Cordero-Sánchez, Servicio de Medicina Interna, Seccion de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de investigacion Biomedica de Salamanca (IBSAL), Universidad de Salamanca, 37007 Salamanca, Spain
Author contributions: Marquez-Batalla S and Fraile-Villarejo E collected the patients clinical data; Gutierrez-Zubiaurre N performed the microbiological analyses; Marquez-Batalla S, Cordero-Sanchez M and Belhassen-Garcia M designed the report and wrote the paper.
Correspondence to: Moncef Belhassen-García, MD, PhD, Servicio de Medicina Interna, Seccion de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de investigacion Biomedica de Salamanca (IBSAL), Universidad de Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain. mbelhassen@hotmail.com
Telephone: +34-923-291306 Fax: +34-923-291131
Received: February 22, 2014 Revised: April 19, 2014 Accepted: April 25, 2014 Published online: July 16, 2014
Abstract
Intravesical bacillus Calmette-Guerin (BCG) instillation has been adopted for the treatment of patients with superficial bladder cancer. Severe adverse events due to local instillation of BCG are uncommon, with an overall rate of serious complications of less than 5%. We report the case of an immunocompetent adult patient with multi-system effects, namely pneumonitis, granulomatous hepatitis and meningitis, who responded well to standard treatment for Mycobacterium bovis. This case highlights the importance of a thorough assessment of this type of patient.
Core tip: Intravesical instillation of bacillus Calmette-Guerin (BCG) is a therapeutic option in bladder cancer. Multi-system effects are a rare complication of this procedure, and certain aspects concerning its diagnosis and treatment are unclear. We report the case of a patient who developed effects on multiple organs after intravesical BCG instillations, and we review current knowledge concerning the diagnosis and management of BCG infection.
