Huffaker T, Pak S, Asif A, Otchere P. Tricuspid mass-curious case of Li-Fraumeni syndrome: A case report. World J Clin Cases 2024; 12(11): 1936-1939 [PMID: 38660548 DOI: 10.12998/wjcc.v12.i11.1936]
Corresponding Author of This Article
Stella Pak, MD, Academic Research, Doctor, Department of Neurology, Albany Medical Center, 47 New Scotland Avenue, Albany, NY 12208, United States. stellacpak@outlook.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 16, 2024; 12(11): 1936-1939 Published online Apr 16, 2024. doi: 10.12998/wjcc.v12.i11.1936
Tricuspid mass-curious case of Li-Fraumeni syndrome: A case report
Tyler Huffaker, Stella Pak, Anum Asif, Prince Otchere
Tyler Huffaker, Anum Asif, Prince Otchere, Department of Cardiology, University of Texas Health San Antonio, San Antonio, TX 78701, United States
Stella Pak, Department of Neurology, Albany Medical Center, Albany, NY 12208, United States
Author contributions: Huffaker T and Pak S contributed to the manuscript writing and revision; Asif A contributed to the revision and image editing; Otchere P contributed to the supervision revision.
Informed consent statement: Written informed consent was obtained for the peripherally inserted central catheter placement.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stella Pak, MD, Academic Research, Doctor, Department of Neurology, Albany Medical Center, 47 New Scotland Avenue, Albany, NY 12208, United States. stellacpak@outlook.com
Received: September 26, 2023 Peer-review started: September 26, 2023 First decision: December 5, 2023 Revised: December 30, 2023 Accepted: February 18, 2024 Article in press: February 18, 2024 Published online: April 16, 2024
Abstract
BACKGROUND
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer-predisposing syndrome, which can manifest as a polymorphic spectrum of malignancies. LFS is associated with an early onset in life, with the majority of cases occurring prior to the age of 46. Notwithstanding the infrequency of primary cardiac tumors, it behooves clinicians to remain vigilant in considering the differential diagnosis of such tumors in LFS patients who present with a cardiac mass. This is due to the markedly elevated risk for malignancy in this particular population, far surpassing that of the general populace.
CASE SUMMARY
Herein, we present a case of a 30-year-old female with LFS who was found to have a tricuspid valve leaflet mass.
CONCLUSION
This case exemplifies valuable learning points in the diagnostic approach for this exceptionally rare patient population.
Core Tip: Li-Fraumeni syndrome is a rare autosomal dominant cancer-predisposing syndrome, which can manifest as a polymorphic spectrum of malignancies.
