Published online Apr 16, 2023. doi: 10.12998/wjcc.v11.i11.2541
Peer-review started: December 26, 2022
First decision: January 12, 2023
Revised: January 27, 2023
Accepted: March 17, 2023
Article in press: March 17, 2023
Published online: April 16, 2023
Juxtaglomerular cell tumor (JGCT) of the kidney, also known as reninoma, is a rare renal tumor that typically clinically manifests as hypertension, hypokalemia, high renin, and high aldosterone. It is a cause of secondary hypertension. Pregnancy with JGCT is rarer and easily misdiagnosed as pregnancy-induced hypertension, thus affecting treatment.
A 28-year-old woman presented in early pregnancy with hypertension (blood pressure of 229/159 mmHg), nausea, and occasional dizziness and headache. The patient was diagnosed with pregnancy-induced hypertension, and no relief was found after symptomatic treatment; hence, the pregnancy was terminated by artificial abortion. Her blood pressure remained high following termination of pregnancy. Blood tests suggested hypokalemia (2.997 mmol/L), blood aldo
Patients with pregnancy complicated by JGCT are difficult to diagnose. Herein, we advise surgeons on proper handling of such situations.
Core Tip: Juxtaglomerular cell tumor (JGCT) is a rare endocrine tumor of the kidney. Typical JGCTs are characterized by high serum renin, high aldosterone secretion, severe hypertension, and severe hypokalemia, known as the “three high and one low” phenomenon. The mainstream treatment is surgery. We report an even rarer case of pregnancy complicated with JGCT, who was misdiagnosed with pregnancy-induced hypertension in a primary hospital, and the pregnancy was terminated artificially due to poor response to conservative treatment. The patient was admitted to our hospital for further treatment because her blood pressure remained high after termination of pregnancy and she was diagnosed with JGCT. The patient recovered well after surgery to remove the tumor. In this article, the case is analyzed retrospectively in the context of the literature in an attempt to explore the diagnosis, treatment, and prognosis of this rare disease.