Masuda S, Tsukiyama T, Minagawa Y, Koizumi K, Kako M, Kinbara T, Haruki U. Hepatocellular carcinoma effective stereotactic body radiotherapy using Gold Anchor and the Synchrony system: Two case reports and review of literature. World J Clin Cases 2022; 10(8): 2591-2603 [PMID: 35434047 DOI: 10.12998/wjcc.v10.i8.2591]
Corresponding Author of This Article
Sakue Masuda, MD, Chief Doctor, Department of Gastroenterology, Shonankamakura General Hospital, 1370-1 Okamoto Kamakura, Kanagawa 247-8533, Japan. sakue.masuda@tokushukai.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2022; 10(8): 2591-2603 Published online Mar 16, 2022. doi: 10.12998/wjcc.v10.i8.2591
Hepatocellular carcinoma effective stereotactic body radiotherapy using Gold Anchor and the Synchrony system: Two case reports and review of literature
Sakue Masuda, Kazuya Koizumi, Makoto Kako, Takeshi Kinbara, Uojima Haruki, Department of Gastroenterology, Shonankamakura General Hospital, Kanagawa 247-8533, Japan
Toshitaka Tsukiyama, Department of Interventional Radiology Center, Shonan Kamakura General Hospital, Kanagawa 247-8533, Japan
Yumiko Minagawa, Department of Radiation Oncology, Shonan Kamakura General Hospital, Kanagawa 247-8533, Japan
Author contributions: Masuda S, Koizumi K, Kako M, Kinbara T, and Uojima H were the patient’s hepatologists, reviewed the literature, and contributed to manuscript drafting; Masuda S and Minagawa Y reviewed the literature and contributed to manuscript drafting; Tsukiyama T and Minagawa Y were the radiologists and performed the radiotherapy and contributed to manuscript drafting; Tsukiyama T analyzed and interpreted the imaging findings; Masuda S, Uojima H, Tsukiyama T, and Minagawa Y were responsible for the revision of the manuscript and for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sakue Masuda, MD, Chief Doctor, Department of Gastroenterology, Shonankamakura General Hospital, 1370-1 Okamoto Kamakura, Kanagawa 247-8533, Japan. sakue.masuda@tokushukai.jp
Received: September 15, 2021 Peer-review started: September 15, 2021 First decision: November 11, 2021 Revised: November 12, 2021 Accepted: January 29, 2022 Article in press: January 29, 2022 Published online: March 16, 2022
Abstract
BACKGROUND
Radiotherapy for hepatocellular carcinoma (HCC) is considered to have limited efficacy because of treatment intensity considering that the irradiated area includes the liver, which is highly radiosensitive. In this report, we present two cases in which tumor control by surgical resection, radiofrequency ablation, transcatheter arterial chemoembolization (TACE), and lenvatinib administration was difficult, but stereotactic body radiotherapy (SBRT) using the Synchrony system by Radixact™ and Gold Anchor® (GA) was effective.
CASE SUMMARY
A 60-year-old man had a single 10-cm HCC in the right lobe. Viable lesions remained after TACE, and levels of alpha-fetoprotein and protein induced by vitamin K antagonists II (PIVKA-II) decreased and quickly re-elevated. We performed SBRT with GA. Three weeks after implantation, localized radiotherapy (SBRT; 40 Gy/5 fractions) was performed using the Synchrony system by Radixact™. Four weeks later, the viable lesion had disappeared, and the PIVKA-II levels decreased. A 77-year-old man had a single 12-cm HCC in the right lobe. The patient experienced recurrence after hepatectomy. Further recurrence occurred after TACE, and we performed SBRT with GA. Because of the proximity of the HCC to the gastrointestinal tract, localized radiotherapy (SBRT; 39 Gy/13 fractions) to the HCC was performed 3 wk after implantation using the Synchrony system by Radixact™. Four weeks later, the viable lesion had disappeared on computed tomography, and the PIVKA-Ⅱ levels decreased.
CONCLUSION
SBRT using the Synchrony system and GA can deliver a large dose accurately and safely, and could have a high therapeutic effect.
Core Tip: Radiotherapy using fiducial markers has been performed for hepatocellular carcinoma (HCC) for several years. However, the Gold Anchor® (GA) used in this report is a new fiducial marker with a small diameter, which is expected to reduce the incidence of complications. The Synchrony system by Radixact™ is also a new radiation device, which is useful in respiratory motion management and allows complete tracking of the HCC in which the GA is implanted. Radiotherapy using these devices was highly effective for HCC that could not be controlled by surgery, transcatheter arterial chemoembolization, or molecular targeted drugs.
