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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Fibrous hamartoma of infancy with bone destruction of the tibia: A case report
Yong-Jie Qiao, Wen-Bin Yang, Yan-Feng Chang, Hao-Qiang Zhang, Xin-Yuan Yu, Sheng-Hu Zhou, Yan-Yan Yang, Lv-Dan Zhang
Yong-Jie Qiao, Yan-Feng Chang, Hao-Qiang Zhang, Xin-Yuan Yu, Sheng-Hu Zhou, Department of Joint Surgery, The 940th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China
Wen-Bin Yang, Department of Orthopedics, The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, Lanzhou 730050, Gansu Province, China
Yan-Yan Yang, Department of Cardiology, Yongjing County People's Hospital of Gansu Province, Lanzhou 730050, Gansu Province, China
Lv-Dan Zhang, Department of Respiratory Medicine, The 940th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China
Author contributions: Qiao YJ, Yang WB, Chang YF and Zhang HQ find the special case;Qiao YJ, Yang WB, Yu XY and Zhou SH performed the research; Qiao YJ, Yang WB, Yang YY and Zhang LD followed up; All authors have read and approve the final manuscript.
Supported by Youth Science and Technology Foundation of Gansu Province, No. 20JR5RA588; Youth Science and Technology Foundation of Gansu Province, No. 21JR7RA014; Key RESEARCH and Development Program of Gansu Province, No. 21YF5FA154.
Informed consent statement: I declare that the participant provided informed consent prior to study inclusion.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Wen-Bin Yang, MD, Doctor, Department of Orthopedics, The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, No. 333 Nanbinghe Road, Qilihe District, Lanzhou 730050, Gansu Province, China. yangwenb218@163.com
Received: July 25, 2022
Peer-review started: July 25, 2022
First decision: August 22, 2022
Revised: August 27, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: October 26, 2022
BACKGROUND
Fibrous hamartoma of infancy (FHI) is a rare disease of infancy with unknown etiology. The disease mainly involves soft tissue, has no specific clinical manifestations, and is difficult to diagnose. At present, the diagnosis is mainly confirmed by histopathological examination, and the main treatment is surgical resection of the pathological tissue, which is prone to recurrence.
CASE SUMMARY
A five-month-old female patient was admitted to our hospital with swelling in the right calf. Two biopsies were performed in our hospital and another hospital, respectively, confirming the diagnosis as fibrous hamartoma. After exclusion of surgical contraindications, resection was performed with clear margins of 1 cm. Radiographic examination showed tumor recurrence more than four months after the operation, and surgery was performed again to extend the resection margins to 1.5 cm. The patient is recovering well, and after a follow-up of 36 mo, shows no signs of recurrence.
CONCLUSION
Our case report demonstrates that FHI should be considered in the differential diagnosis for a lower extremity mass with bone destruction. For FHI with bone destruction and unclear boundaries, excision margins of 1.5 cm could be superior to margins of 1 cm.
Core Tip: Fibrous hamartoma of infancy (FHI) is a rare disease of infancy with unknown etiology. The disease mainly involves soft tissue, has no specific clinical anifestations, and is difficult to diagnose. At present, the diagnosis is mainly confirmed by histopathological examination, and the main treatment is surgical resection of the pathological tissue, which is prone to recurrence. Our case report demonstrates that FHI should be considered as part of the differential diagnosis for a lower extremity mass with bone destruction. For FHI with bone destruction and unclear boundaries, excision margins of 1.5 cm are superior to margins of 1 cm.
