Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2022; 10(26): 9417-9427
Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9417
Noncirrhotic portal hypertension due to peripheral T-cell lymphoma, not otherwise specified: A case report
Miao-Miao Wu, Wen-Jun Fu, Jia Wu, Lin-Lin Zhu, Ting Niu, Rong Yang, Jin Yao, Qiang Lu, Xiao-Yang Liao
Miao-Miao Wu, Wen-Jun Fu, Jia Wu, Lin-Lin Zhu, Rong Yang, Xiao-Yang Liao, General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Ting Niu, Department of Haematology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Jin Yao, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Qiang Lu, Department of Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Liao XY designed and performed the research; Wu MM analysed the data and wrote the paper; Wu J, Niu T, and Fu WJ cared for the patient, designed and analysed the research, and helped with writing the paper; Zhu LL, and Yang R participated in revising the manuscript; Lu Q carried out the ultrasound; Yao J performed imaging studies; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist. (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Yang Liao, MS, Chief Physician, Professor, General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, No. 37 GuoXueXiang Street, Chengdu 610041, Sichuan Province, China. liaoxiaoyang@wchscu.cn
Received: April 25, 2022
Peer-review started: April 25, 2022
First decision: June 8, 2022
Revised: June 20, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: September 16, 2022
Processing time: 129 Days and 15 Hours
Abstract
BACKGROUND

Peripheral T-cell lymphoma (PTCL), an aggressive and rare disease that belongs to a heterogeneous group of mature T-cell lymphomas, develops rapidly and has a poor prognosis. Early detection and treatment are essential to improve patient cure and survival rates. Here, we report a rare case of PTCL with clinical presentation of noncirrhotic portal hypertension, which provides a basis for early vigilance of lymphomas in the future.

CASE SUMMARY

A 65-year-old Chinese woman was admitted to our hospital because of abdominal distension for 3 months and pitting oedema of both lower limbs for 2 months. Physical examinations and associated auxiliary examinations showed the presence of hepatosplenomegaly, and her hepatic venous pressure gradient was 10 mmHg. Immunohistochemical analysis of the liver biopsy confirmed the diagnosis of PTCL. The patient underwent combination therapy with dexamethasone, VP-16, and chidamide. Unfortunately, after 41 days of chemotherapy, the patient died of multiple organ failure.

CONCLUSION

PCTL accompanied by noncirrhotic portal hypertension is rarely reported. This case report discusses the diagnosis of a patient according to the literature.

Keywords: Noncirrhotic portal hypertension; Ascites; Peripheral T-cell lymphoma; Lymphoma; Chidamide; Case report

Core Tip: Peripheral T-cell lymphoma (PTCL) is an aggressive and rare disease that belongs to a heterogeneous group of mature T-cell lymphomas, and is classified as PTCL, not otherwise specified (PTCL-NOS). It is the most common type and most often involves nodal sites; however, many patients present with extranodal involvement, including the liver, bone marrow, gastrointestinal tract, and skin. The clinical presentations of PTCL are lymphadenopathy syndrome and B symptoms (night sweats, fever, and weight loss). Noncirrhotic portal hypertension, hydrothorax and ascites can also occur in rare cases, and noncirrhotic portal hypertension and ascites are less common as first symptoms. Here, we report a rare case of a patient with PTCL who presented with noncirrhotic portal hypertension.