Ma ML, He LP. Electroconvulsive therapy plays an irreplaceable role in treatment of major depressive disorder. World J Clin Cases 2022; 10(16): 5515-5517 [PMID: 35812666 DOI: 10.12998/wjcc.v10.i16.5515]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2022; 10(16): 5515-5517 Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5515
Electroconvulsive therapy plays an irreplaceable role in treatment of major depressive disorder
Mei-Lin Ma, Lian-Ping He
Mei-Lin Ma, Lian-Ping He, School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China
Author contributions: Ma ML contributed to the conception of the research and wrote the letter; He LP contributed to the revision of the letter; all authors approved the final manuscript for submission.
Supported bythe Curriculum Reform Project of Taizhou University in 2021, No. xkg2021087.
Conflict-of-interest statement: The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: February 25, 2022 Peer-review started: February 25, 2022 First decision: April 18, 2022 Revised: April 20, 2022 Accepted: May 5, 2022 Article in press: May 5, 2022 Published online: June 6, 2022
Abstract
Major depressive disorder is a serious and common neuropsychiatric disorder that affects more than 350 million people worldwide. Electroconvulsive therapy is the oldest and most effective treatment available for the treatment of severe major depressive disorder. Electroconvulsive therapy modifies structural network changes in patients with major depressive disorder and schizophrenia. And it can also affect neuroinflammatory responses and may have neuroprotective effects. Electroconvulsive therapy plays an irreplaceable role in the treatment of major depressive disorder.
Core Tip: Electroconvulsive therapy has been shown to be very useful for the acute treatment of major depressive, manic, and mixed states, especially those with a high degree of suicide, as well as catatonic and drug-resistant depression. It should not be seen as a second line of defense after drug therapy.
