World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients

Table 6 Orphan diseases with the most orphan drug approvals

Disease	Drugdesignation	Drugsapproved
AIDS	57	8
Acute myeloid leukaemia	34	5
Ovarian cancer	34	4
Multiple myeloma	32	6
Glioma	29	4
Chronic myelogenous leukaemia	19	4
Acute lymphoblastic leukaemia	17	6
Pneumocystis carinii pneumonia	15	5
Respiratory distress syndrome, infant	14	6
Multiple sclerosis	14	5
Growth hormone deficiency	13	9
Idiopathic pulmonary hypertension	12	4
Kaposi's sarcoma	11	5
Malaria	11	4

Adapted from ref[48,49]. AIDS: Acquired immunodeficiency syndrome.