World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients

Table 1 Main causes of death in developed and developing countries excluding malnutrition

People indevelopedcountries(2002)	Millions	People in Developing countries (2002)	Millions	Globally(2011)	Millions
Heart attack	3.08	LRTI	2.81	Heart attack	7.00
Stroke	1.78	HIV/AIDS	2.55	Stroke	6.20
LTB cancer	0.61	Heart attacks	2.53	LRTI	3.20
LRTI	0.45	Infections at birth	1.78	COPD	3.00
COPD	0.42	Diarrhoeal disease	1.53	Diarrhoeal disease	1.90
Colon, rectal cancer	0.35	Stroke	1.45	HIV/AIDS	1.60
Diabetes	0.24	Malaria	1.25	Diabetes	1.50
Self inflicted injuries	0.23	Tuberculosis	0.96	LTB Cancer	1.40
Hypertensive heart disease	0.23	COPD	0.76	Road injuries	1.30
All causes	13.43	All causes	27.12
Estimates 20061		Malnutrition	36.00	All causes	62.00

¹The total number of deaths globally in 2006 was estimated to be about 62 million, of which 32 million were related to hunger and malnutrition. COPD: Chronic obstructive pulmonary disease; LRTI: Lower respiratory tract infections; LTB cancer: Lung, tracheal and bronchial cancer. Adapted from ref[22-28].