Review of treatment assessment using DCE-MRI in breast cancer radiation therapy

Table 1 Dynamic contrast-enhanced magnetic resonance imaging parameter correlations with physiological parameters at breast tissue

Ref.	Correlation		Direction of correlation	P
	Physiological parameter	DCE-MRI measurement
Buadu et al[76], 1996	MVD	Amplitude	+	< 0.01
		Slope maximum	+	< 0.01
		Enhancement Maximum time	-	< 0.01
		Tumor size	..	NS
Stomper et al[77], 1996	DNA S-phase percentage	Signal enhancement amplitude	..	NS
		Signal enhancement rate	..	NS
		Signal washout	..	NS
Hulka et al[78], 1997	Tumor grade	RSI	+	< 0.01
Matsubayashi et al[79], 2000	Peripheral-central MVD ratio	Early rim enhancement	+	0.048
	Peripheral-central fibrosis ratio	Early rim enhancement	-	< 0.01
	Central-peripheral fibrosis ratio	Delayed rim	+	0.013
Gianfelice et al[80], 2003	Residue tumor percentage after MRIgFUS	ISI	+	NR
		MDF	+	NR
		PEI	+	NR
Su et al[81], 2003	VEGF	Apparent Vb	..	NS
		In-flux rate and distribution volume in interstitial space (VeK1)	..	NS
		Out-flux rate (K2)	..	NS

NS: Not significant; NR: Not reported; RSI: Relative signal intensity; MVD: Microvessel density; ISI: Increase in signal intensity; MDF: Maximum difference function; PEI: Positive enhancement interal; Vb: Vascular volume; VEGF: Vascular endothelial growth factor.