Glucagon-like receptor-1 agonists and impotence: A meta-analysis

doi:10.5662/wjm.119385

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World Journal of Methodology

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2222-0682

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Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Methodol. Sep 20, 2026; 16(3): 119385
Published online Sep 20, 2026. doi: 10.5662/wjm.119385

Table 4 Analysis of the quality of evidence by GRADE

Outcome	Studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	GRADE
ED	7	Trial = 1, retrospective = 4, pilot study = 1	Serious	Serious (I² = 90%)	Not serious	Not serious	None	Very low
TT	6	Trial = 1, retrospective = 3, pilot study = 1	Serious	Serious (I² = 99%)	Not serious	Not serious	None	Very low
FT	5	Trial = 1, retrospective = 3, pilot study = 1	Serious	Serious (I² = 86%)	Not serious	Not serious	None	Very low
SHBG	6	Trial = 1, retrospective = 4, pilot study = 1	Serious	Serious (I² = 99%)	Not serious	Not serious	None	Very low
LH	5	Trial = 1, retrospective = 3, pilot study = 1	Serious	Serious (I² = 91%)	Not serious	Not serious	None	Very low
FSH	5	Trial = 1, retrospective = 3, pilot study = 1	Serious	Serious (I² = 91%)	Not serious	Not serious	None	Very low

ED: Erectile dysfunction; TT: Total; FT: Free testosterone; SHBG: Sex hormone binding globulins; LH: Luteinizing hormone; FSH: Follicular stimulating hormone; GLP-1 agonists: Glucagon-like peptide receptors-1 agonists.

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Citation: Mirghani HO, AlQurashi AM. Glucagon-like receptor-1 agonists and impotence: A meta-analysis. World J Methodol 2026; 16(3): 119385
URL: https://www.wjgnet.com/2222-0682/full/v16/i3/119385.htm
DOI: https://dx.doi.org/10.5662/wjm.119385

Mirghani HO, AlQurashi AM. Glucagon-like receptor-1 agonists and impotence: A meta-analysis. World J Methodol 2026; 16(3): 119385 [DOI: 10.5662/wjm.119385]

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