Anti-obesity medications impacting the eye: An emerging concern - a narrative review

doi:10.5662/wjm.118520

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World Journal of Methodology

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2222-0682

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World J Methodol. Sep 20, 2026; 16(3): 118520
Published online Sep 20, 2026. doi: 10.5662/wjm.118520

Table 2 Mechanisms of anti-obesity drug-induced visual impairment

Mechanism	Description	Examples
Vascular	Ischemia due to altered ocular blood flow or microvascular injury	GLP-1 receptor agonists (NAION)
Metabolic	Indirect effects, such as rapid glycemic improvement or hepatic dysfunction	GLP-1 receptor agonists (DR)
Direct drug toxicity	Physical or chemical injury to ocular structures	Topiramate (anatomic shift, effusion)

GLP-1 RA: Glucagon-like peptide-1 receptor agonist; NAAION: Non-arteritic anterior ischemic optic neuropathy; DR: Diabetic retinopathy.

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Citation: Khullar S, Morya AK, Aggarwal S, Singh A, Sisodiya P, Morya R. Anti-obesity medications impacting the eye: An emerging concern - a narrative review. World J Methodol 2026; 16(3): 118520
URL: https://www.wjgnet.com/2222-0682/full/v16/i3/118520.htm
DOI: https://dx.doi.org/10.5662/wjm.118520

Khullar S, Morya AK, Aggarwal S, Singh A, Sisodiya P, Morya R. Anti-obesity medications impacting the eye: An emerging concern - a narrative review. World J Methodol 2026; 16(3): 118520 [DOI: 10.5662/wjm.118520]

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