Functional dyspepsia and risk of Barrett’s esophagus and dysplasia: A propensity-matched multicenter retrospective cohort study

doi:10.5662/wjm.117891

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World Journal of Methodology

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2222-0682

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Methodol. Sep 20, 2026; 16(3): 117891
Published online Sep 20, 2026. doi: 10.5662/wjm.117891

Table 2 Primary and secondary outcomes in the two cohorts, n (%)

Outcome	Patients with outcome in the FD cohort (n = 384267)	Patients with outcome in the control cohort (n = 384267)	Hazard ratio (95%CI)	Log rank P value
Barrett’s esophagus	4105 (1.07)	3790 (0.99)	1.900 (1.813-1.991)	< 0.001
Barrett’s-associated dysplasia	454 (0.12)	349 (0.09)	3.568 (3.064-4.155)	< 0.001
Esophageal cancer	524 (0.14)	516 (0.13)	1.649 (1.450-1.875)	< 0.001

FD: Functional dyspepsia; CI: Confidence interval.

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Citation: Maan MHA, Maan S, Waleed M, Ahmad MM, Goyal RM, Sohail AH, Abboud Y, Khan S, Gayam S, Kupec J. Functional dyspepsia and risk of Barrett’s esophagus and dysplasia: A propensity-matched multicenter retrospective cohort study. World J Methodol 2026; 16(3): 117891
URL: https://www.wjgnet.com/2222-0682/full/v16/i3/117891.htm
DOI: https://dx.doi.org/10.5662/wjm.117891

Maan MHA, Maan S, Waleed M, Ahmad MM, Goyal RM, Sohail AH, Abboud Y, Khan S, Gayam S, Kupec J. Functional dyspepsia and risk of Barrett’s esophagus and dysplasia: A propensity-matched multicenter retrospective cohort study. World J Methodol 2026; 16(3): 117891 [DOI: 10.5662/wjm.117891]

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