Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review

doi:10.5662/wjm.v16.i2.113265

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World Journal of Methodology

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2222-0682

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World J Methodol. Jun 20, 2026; 16(2): 113265
Published online Jun 20, 2026. doi: 10.5662/wjm.v16.i2.113265

Table 4 GRADE evidence assessment¹

Comparison	Outcome	Studies	Design	Risk of bias	Inconsistency	Indirectness	Imprecision	Certainty
Any anticoagulant vs control	Thrombotic events	1 RCT, 8 Obs	Mixed	Serious	Not serious	Not serious	Serious	Low
Fondaparinux vs others	Thrombotic events	5 Obs	Observational	Serious	Serious	Not serious	Serious	Very low
Argatroban vs bivalirudin	Thrombotic events	3 Obs	Observational	Serious	Not serious	Not serious	Serious	Low
Any anticoagulant vs control	Major bleeding	1 RCT, 10 Obs	Mixed	Serious	Serious	Not serious	Serious	Very low
Any anticoagulant vs control	Mortality	1 RCT, 8 Obs	Mixed	Serious	Serious	Not serious	Serious	Very low

¹All major comparisons and outcomes provided a low to very low overall certainty of the evidence due to the dominance of observational study designs, risk of bias issues, and imprecision resulting from small sample sizes.

GRADE: Grading of Recommendations Assessment, Development and Evaluation; RCT: Randomized controlled trials; Obs: Observational.

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Citation: Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265
URL: https://www.wjgnet.com/2222-0682/full/v16/i2/113265.htm
DOI: https://dx.doi.org/10.5662/wjm.v16.i2.113265

Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265 [PMID: 42058815 DOI: 10.5662/wjm.v16.i2.113265]

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