Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review

Table 2 Risk of bias assessment¹

Ref.	Study design	Selection	Comparability	Outcome assessment	Overall quality
Boyce et al[5] (2011)	RCT	Low risk	Low risk	Low risk	Good
Joseph et al[6] (2014)	Observational	Moderate risk	High risk	Moderate risk	Fair
Bain and Meyer[9] (2015)	Observational	Moderate risk	Moderate risk	Moderate risk	Fair
Duewell et al[10] (2021)	Observational	Moderate risk	Moderate risk	Low risk	Fair
Al-Eidan et al[8] (2018)	Observational	High risk	High risk	Moderate risk	Poor
Marchetti et al[11] (2022)	Observational	Moderate risk	High risk	Low risk	Fair
Davis et al[25] (2022)	Observational	Moderate risk	High risk	Moderate risk	Fair
Albuloushi et al[26] (2022)	Observational	Moderate risk	High risk	Moderate risk	Fair
Snodgrass et al[13] (2016)	Observational	High risk	High risk	Moderate risk	Poor
Pishko et al[15] (2019)	Observational	Low risk	Moderate risk	Low risk	Good
Carré et al[27] (2021)	Observational	High risk	High risk	Moderate risk	Poor
Schindewolf et al[7] (2017)	Observational	Low risk	Moderate risk	Low risk	Good
Kang et al[12] (2015)	Observational	Moderate risk	Moderate risk	Moderate risk	Fair
Tardy-Poncet et al[28] (2015)	Observational	Moderate risk	High risk	Low risk	Fair
Nand et al[3] (1997)	Observational	High risk	High risk	High risk	Poor
Dulicek et al[14] (2019)	Observational	High risk	High risk	Moderate risk	Poor

¹The inter-reviewer agreement for risk of bias assessment was assessed good (κ = 0.72).

RCT: Randomized controlled trials.