Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review

doi:10.5662/wjm.v16.i2.113265

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World Journal of Methodology

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World J Methodol. Jun 20, 2026; 16(2): 113265
Published online Jun 20, 2026. doi: 10.5662/wjm.v16.i2.113265

Table 1 Characteristics of included studies

Ref.	Design	Setting	Patients (n)/mean age	HIT diagnosis	Interventions	Follow-up
Boyce et al[5] (2011)	RCT	Multi-center	50/62.5	Suspected HIT	Desirudin vs argatroban	35 days
Joseph et al[6] (2014)	Retrospective cohort	Single center	133/61.0	Confirmed/suspected	Bivalirudin	Hospital stay
Bain and Meyer[9] (2015)	Retrospective cohort	Single center	89/66.2	Confirmed/suspected	Bivalirudin vs lepirudin vs Argatroban	Hospital stay
Duewell et al[10] (2021)	Retrospective cohort	Multi-center	167/64.8	Suspected/confirmed	Argatroban vs bivalirudin	30 days
Al-Eidan et al[8] (2018)	Retrospective cohort	Single center	34/65.4	Isolated HIT	Argatroban vs fondaparinux	Hospital stay
Marchetti et al[11] (2022)	Retrospective cohort	Single center	32/68.5	Confirmed HIT	Argatroban	Treatment period
Davis et al[25] (2022)	Retrospective cohort	Multi-center	135/63.2	Confirmed/Suspected	DOACs	90 days
Albuloushi et al[26] (2022)	Retrospective cohort	Single center	48/66.8	HIT	DOACs	30 days
Snodgrass et al[13] (2016)	Retrospective cohort	Single center	43/61.7	Suspected HIT	Fondaparinux	Hospital stay
Pishko et al[15] (2019)	Retrospective cohort	Multi-center	1291/63.1	Suspected HIT	Various	30 days
Carré et al[27] (2021)	Retrospective case series	Single center	22/69.0	HIT	DOACs	6 months
Schindewolf et al[7] (2017)	Retrospective cohort	Multi-center	616/67.2	HIT	Fondaparinux vs others	Hospital stay
Kang et al[12] (2015)	Retrospective cohort	Single center	78/64.5	Suspected HIT	Fondaparinux	30 days
Tardy-Poncet et al[28] (2015)	Prospective cohort	Multi-center	62/66.8	Confirmed HIT	Argatroban	Treatment period
Nand et al[3] (1997)	Retrospective cohort	Single center	108/59.4	HIT with thrombosis	Various	Hospital stay
Dulicek et al[14] (2019)	Retrospective cohort	Single center	37/68.9	HIT	Fondaparinux	Treatment period

RCT: Randomized controlled trials; HIT: Heparin-induced thrombocytopenia; DOACs: Direct acting oral anticoagulants.

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Citation: Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265
URL: https://www.wjgnet.com/2222-0682/full/v16/i2/113265.htm
DOI: https://dx.doi.org/10.5662/wjm.v16.i2.113265

Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265 [PMID: 42058815 DOI: 10.5662/wjm.v16.i2.113265]

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