Direct oral anticoagulants vs LMWH for cancer-associated thrombosis - updated evidence on bleeding risk, recurrence and patient-reported outcomes: A systematic review

Table 2 Quality assessment for randomized controlled trials (Cochrane risk of bias tool)

Ref.	Randomization process	Deviations from intended interventions	Missing outcome data	Measurement of outcomes	Selection of reported results	Overall risk of bias
Agnelli et al[4]	Low	Some concerns	Low	Low	Low	Some concerns
McBane et al[6]	Low	Some concerns	Low	Low	Low	Some concerns
Raskob et al[8]	Low	Some concerns	Some concerns	Low	Low	Some concerns
Young et al[10]	Low	Some concerns	Low	Low	Low	Some concerns
Marshall et al[5]	Low	Some concerns	Low	Low	Low	Some concerns
Planquette et al[7]	Low	Some concerns	Low	Low	Low	Some concerns
Lee et al[29]	Low	Low	Low	Low	Low	Low
Lee et al[2]	Low	Low	Some concerns	Low	Low	Some concerns
Schrag et al[9]	Low	Some concerns	Low	Low	Low	Some concerns
Hull et al[27]	Some concerns	Some concerns	Some concerns	Low	Low	Some concerns
Deitcher et al[30]	Some concerns	High	Some concerns	Low	Low	High
Riess et al[23]	Some concerns	Some concerns	Low	Some concerns	Low	Some concerns
Di Nisio et al[21]	Low	Some concerns	Low	Low	Low	Some concerns
Mulder et al[22]	Low	Some concerns	Low	Low	Low	Some concerns
Kraaijpoel et al[24]	Low	Some concerns	Low	Low	Low	Some concerns

Low: Low risk of bias; Some concerns: Some concerns about bias; High: High risk of bias.