Radiation therapy plus osimertinib vs osimertinib alone in epidermal growth factor receptor mutated non-small cell lung cancer: A systematic review

Table 3 Quality assessment for observational studies (Newcastle-Ottawa scale)

Ref.	Selection (0-4)	Comparability (0-2)	Outcome (0-3)	Total score	Quality rating
Shi et al[2], PIONEER	4	2	3	9	High
Gu et al[31]	3	1	3	7	High
Rangachari et al[3]	4	2	2	8	High
Magnuson et al[27], 2016	3	2	3	8	High
Ballard et al[8]	3	1	2	6	Moderate
Magnuson et al[28], 2017	4	2	3	9	High
Chen et al[29]	3	2	3	8	High
Miyawaki et al[30]	3	2	3	8	High
Iuchi et al[5]	2	1	2	5	Moderate
Eichler et al[4]	3	2	2	7	High
Yamamoto et al[33]	4	1	3	8	High
Tatineni et al[32]	3	2	3	8	High
Yan et al[20]	2	1	2	5	Moderate
Hsu et al[6]	3	2	2	7	High
Zhong et al[21]	2	1	2	5	Moderate
Pan et al[34]	3	2	2	7	High
Dohm et al[22]	4	2	3	9	High

Newcastle-Ottawa Scale scoring: Selection (representativeness, selection of controls, ascertainment of exposure, outcome not present at baseline), Comparability (design and analysis), Outcome (assessment, follow-up length, adequacy). High quality: ≥ 7 points; Moderate quality: 5-6 points; Low quality: < 5 points.