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©The Author(s) 2025.
World J Methodol. Dec 20, 2025; 15(4): 99785
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.99785
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.99785
Table 1 Basic characteristics and imaging results among patients with irritable bowel syndrome, mean ± SD
Ref. | Country | Study design | Sample size | Age/years | Females, % | Main result |
Klinge et al[19], 2022 | Denmark | Case-control | 20 | 25-53 | 76% | Low colonic volume and rapid transit time among IBS patients compared to chronic constipation |
Lam et al[20], 2016 | United Kingdom | Case-control | 48 | 27-53 | 91.3% | Higher ascending colon volume in functional constipation compared to IBS patients |
Pritchard et al[21], 2014 | United Kingdom | Case-control | 50 | 39 ± 13 | 58.7% | Less ascending colon postprandial volume and high descending colon volume among IBS compared to healthy controls |
Di Palma et al[28], 2011 | Italy | Case-control | 40 | 31 ± 7 | 66.7% | Rectal volume was smaller among IBS patients |
Nilsson et al[34], 2015 | Denmark | Cross-sectional | 25 | Not mentioned | All males | No inter-individual and intra-individual variability in colonic volume MRI |
Grinsvall et al[38], 2021 | Sweden | Case-control | 354 | 27.9 ± 9.9 | All females | Low grey matter volume in the posterior insula and superior frontal gyrus with high grey matter volume and cortical thickness in the somatosensory cortex and subcortical regions |
Blankstein et al[39], 2010 | Canada | Case-control | 27 | 30.85 ± 8.9 | All females | Increased gray matter in hypothalamus among patients with IBS, and anterior midcingulate cortical thinning |
Chua et al[40], 2017 | Taiwan | Case-control | 69 | 36.7 ± 7.7 | All females | Supramarginal cortex, middle frontal cortex, and left cuneus showed cortical thinning in IBS patients with a negative correlation with the disease severity |
Jiang et al[42], 2013 | United States | Case-control | 266 | 34.72 ± 11.12 | 84.6% | No difference in cortical thickness between IBS patients and control subjects. Cortical thickness decreases in the bilateral subgenual anterior cingulate cortex, and increases in the somatosensory and primary motor cortex among women with IBS |
Mao et al[43], 2020 | China | Cross-sectional | 68 | Not mentioned | Diarrhhea predominant subjects | Enlarged caudate nucleus and thalamus, and altered hemispheric asymmetries among diarrhea-predominant IBS patients |
Chen et al[44], 2011 | Canada | Cross-sectional | 26 | 20-54 | All females | Mean fractional anisotropy was observed in IBS patients in the fornix and external capsules |
Zhao et al[45], 2018 | China | Case-control | 30 | 77.5 ± 6.3 | 20% | Gray matter volume is low in occipital and frontal lobes, limbic and hippocampus, and high in angular and temporal gyrus, and insula |
Icenhour et al[50], 2017 | Sweden | Case-control | 61 | 32-36 | All females | Resting-state functional connectivity is reduced in the amygdala and insula in IBS patients |
Guleria et al[51], 2017 | India | Case-control | 20 | 30.5 | All males | Homeostatic emotions, autonomic responses to pain, and affective motivation differ in IBS patients compared to controls |
- Citation: Mirghani HO. Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review. World J Methodol 2025; 15(4): 99785
- URL: https://www.wjgnet.com/2222-0682/full/v15/i4/99785.htm
- DOI: https://dx.doi.org/10.5662/wjm.v15.i4.99785