Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment

doi:10.5662/wjm.v15.i4.105775

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Dec 20, 2025 (publication date) through Aug 4, 2025

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Dec 20, 2025; 15(4): 105775
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.105775

Table 2 Comparison of convulsion rate and mortality of mice in each group

Group	Convulsion rate (%)	H value	P value	Mortality rate (%)	H value	P value
Low-dose MgSO₄ group	90	0.00	> 0.99	70	0.471	> 0.99
Medium-dose MgSO₄ group	60	0.668	> 0.99	30	5.051	0.356
High-dose MgSO₄ group	20	2.670	0.045^a	10	9.899	< 0.01^b

^aP < 0.05, differences are statistically significant.

^bP < 0.01, statistical differences are highly significant.

Control group: The control group in this study was the saline control group, in which mice received an equal volume of saline solution without magnesium sulfate. MgSO₄: Magnesium sulfate.

Citation: Xu DJ, Zhong Q, Wang GT, Lu X. Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment. World J Methodol 2025; 15(4): 105775
URL: https://www.wjgnet.com/2222-0682/full/v15/i4/105775.htm
DOI: https://dx.doi.org/10.5662/wjm.v15.i4.105775