Cytoprotective effect of prostacyclin on hepatic ischemia-reperfusion injury

Table 4 Summarizing the main characteristics of the studies after 2000 regarding effects of prostacyclin analogs on hepatic ischemia-reperfusion injury

Ref.	Prostacyclin analog	Dose	Intervention	Species	Study size	Outcome
Neumann et al[171], 2000	Epoprostenol	4 ng/kg/min i.v for 7 days	Continuous infusion after liver transplantation	Human	15	Improvement of hepatic-splanchnic oxygenation
Chen et al[180], 2001	OP-2507	1 μg/kg/min, 0.1 μg/kg/min	Hepatic ischemia	Sprague-Dawley rats	24	Ameliorated ischemia-reperfusion of the liver
Zardi et al[174], 2006	Iloprost	2 ng/kg/min, 6 h/day for 5 days	Portal flow velocity evaluation	Human	15	Improved hepatic perfusion
Gedik et al[188], 2009	Iloprost	10 μg/kg	45 min hepatic ischemia followed by reperfusion	Sprague-Dawley rats	10	Hepatoprotective effects
Ghonem et al[191], 2012	Treprostinil	100 ng/kg/min	Donor and recipient treatment prior liver transplantation	Lewis rats	58	Ameliorated hepatic injury reduced cytokines expression and improved CYP450 activity
Deng et al[28], 2018	Beraprost sodium	50-100 μg/kg	Hepatic ischemia-reperfusion	Mice	36	Ameliorated hepatic IR injury by suppressing inflammation, apoptosis, and autophagy
Almazroo et al[193], 2022	Treprostinil	20 ng/mL of storage solution	Hepatic ischemia-reperfusion	Sprague-Dawley rats	8	Reduced liver injury