Cytoprotective effect of prostacyclin on hepatic ischemia-reperfusion injury

Table 3 Summarizing the main characteristics of the studies before 2000 regarding effects of prostacyclin analogs on hepatic ischemia-reperfusion injury

Ref.	Prostacyclin analog	Dose	Intervention	Species	Study size	Outcome
Monden et al[152], 1982	PGI2	100 μg	Liver preservation for orthotopic liver transplantation	Mongrel dogs	6	100% 48 hours survival
Sikujara et al[155], 1983	PGI2	350 ng/kg/min i.v	75 min Hepatic ischemia	Wistar rats	31	67% one-week survival
Tanaka et al[186], 1990	aPGI2	350 ng/kg/min for 60 min i.v	90 min Hepatic ischemia	Rats		No effect alone
Sanchez-Urdazpal et al[172], 1991	Iloprost	200 μl/L storage solution. 3 μg/kg/min bolus administration through the aortic patch	Liver graft preservation	Lewis rats	12	91% survival
Goto et al[154], 1992	OP-41483	500 ng/kg/min i.v	Liver transplantation	Wistar rats	7	86% one-week survival
Abe et al[176], 1993	OP-41483	400 ng/kg/min	40 min normothermic liver ischemia	Wistar rats	8	Improved microcirculation and increased effective hepatic blood flow
Kim et al[156], 1994	OP-2507	2 pg/kg/min for 30 min, intraportal infusion 200 μg/l	Liver donor pretreatment, graft preservation. Dissolution in preservation solution	Mongrel pigs	6	Improved 5-day survival
Kim et al[157], 1994	OP-2507	2 pg/kg/min for 30 min via mesenteric vein administration	1 hour complete hepatic vascular exclusion	Mongrel pigs	7	86% 5-day survival
Anthuber et al[170], 1996	Epoprostenol	50 μg/ml solution	Liver donor bolus pretreatment	Lewis rats	8	Improved perfusion of liver sinusoids, reduced leukocyte adherence, increased bile production
Klein et al[195], 1999	Epoprostenol	500 μg	Orthotopic liver transplantation	Human	57	Reduced ischemia-reperfusion injury

PGI₂: Prostacyclin.