“Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis ― general presentation

Table 2 A simulation applied on a respiratory clinical and paraclinical picture example

A respiratory CPP example	The possible clusters that may partially or integrally explain the given respiratory CPP (%)	The possible diseases that may explain the possible clusters found by EPed
This CPP example contains these 7 listed signs (which are simultaneously processed as a single CPP	EPed has found many possible clusters that may partially explain the given respiratory CPP (the percent in parentheses represents the degree by which that specific cluster theoretically/potentially explains the given CPP	EPed has found many possible diseases that may explain the possible clusters found by EPed
Cough (“tuse”)	Systemic (biological) inflammatory syndrome (57%)	Tuberculosis (CSD = 1.1)
Fever (“febra”)	Systemic dissemination of Mycobacterium tuberculosis (42%)	Viral pneumonia (CSD = 1.1)
Wheezing (“wheezing”)	Broncho-esophageal fistula (42%)	Bacterial pneumonia (CSD = 1)
Increased erythrocyte sedimentation rate (ESR) (“VSH crescut”)	Tracheo-esophageal fistula (42%)	COVID-19 (CSD = 0.9)
Thrombocytopenia (“trombocitopenie”)	Bronchiolitis (a cluster defined by EPed as an inflammation of bronchioli) (28%)	Scarlet fever (CSD = 0.9)
Neutrophilia (“neutrofilie”)	Bronchiolitis obliterans (28%)	Acute viral diarrhea (CSD = 0.8)
Monocytosis (“monocitoza”)	Respiratory failure (28%)	Viral URTI (CSD = 0.8)
	Pericarditis (28%)	Bronchiolitis (CSD = 0.6)
	Functional respiratory syndrome of obstructive type (28%)	Measles (CSD = 0.5)
	Dehydration (28%)	Influenza (CSD = 0.5)
	Pleurisy (28%)	Congenital broncho-esophageal fistula (disease) (CSD = 0.5)
	Alveolar pneumonia (28%)	Congenital tracheo-esophageal fistula (disease) (CSD = 0.5)
	Interstitial pneumonia (28%)	Bacterial URTI (CSD = 0.4)
	Bronchitis (14%)	Infectious mononucleosis with EBV or/and CMV (CSD = 0.4)
	Carditis (pancarditis) (14%)	Cystic fibrosis (CSD = 0.4)
	Gastroesophageal reflux disease (14%)	Bacterial epiglottitis (CSD = 0.3)
	Rhinitis (a cluster defined by EPed as an inflammation of the nasal mucosa) (14%)	Viral laryngeal tracheitis (CSD = 0.2)
	Adenoiditis (a cluster defined by EPed as an inflammation of the nasal adenoids) (14%)	Periamygdalian abscess (phlegmon) (CSD = 0.2)
	Bacteremia (14%)	Cervical adenoflegmon (CSD = 0.2)
	Cholangitis (14%)	Asthma (CSD = 0.2)
	Endocarditis (14%)	Gastroesophageal reflux disease (CSD = 0.1)
	[…]	Hiatal hernia (CSD = 0.1)
	Pyelonephritis (14%)	etc.
	Sepsis (14%)
	Toxic bacterial syndrome (14%)
	SIRS (14%)
	CNS tuberculoma (14%)
	Viremia (14%)
	Hypersplenism (14%)
	Vasculitis (14%)
	etc.

CPP: Clinico-paraclinical picture; EPed: Electronic Pediatrician.