Variations in quantifying patient reported outcome measures to estimate treatment effect

Table 1 Measurement indices to quantify patient-reported outcomes measures for clinical relevance

Measure of change	Satisfaction threshold
Minimal clinically important difference	Patient acceptable symptom state
Minimal important change	Substantial clinical benefit
Minimal clinically important change
Minimal clinically important improvement
Minimal clinically significant difference
Minimal perceptible clinical improvement
Clinically important difference
Minimal important difference
Minimum detectable change
Minimal detectable difference
Smallest detectable difference