Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology

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2222-0682

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World J Methodol. Jun 20, 2025; 15(2): 101430
Published online Jun 20, 2025. doi: 10.5662/wjm.v15.i2.101430

Table 1 Potential roles of probiotics and fecal microbiota transplantation in alleviating or preventing allergic diseases[99]

Probiotics and FMT	Potential roles
Probiotics	Epithelial integrity ↑
	Tight junction protein expression ↑
	Bacterial translocation ↓
	Inflammatory cytokines such as IL-6, IL-8 and TNF-α ↓
	Restoration of Th1/Th2 balance
	Treg cell numbers and function, IL-10 and TGF-β ↑
	SCFAs production (especially butyrate) ↑
FMT	Pro-inflammatory cytokine secretion ↓
	Restoration of Th1/Th2 balance
	Stimulates T cell activity and leukocyte adhesion
	Change in intestinal bacterial diversity (Firmicutes, Bacteroidetes ↑/Proteobacteria, Actinobacteria ↓)
	Intestinal permeability ↓
	Epithelial integrity ↑
	SCFAs production ↑
	Intestinal pH ↓
	Bacterial adhesion to H₂O₂ ↑

SCFA: Short chain fatty acid; FMT: Fecal microbiota transplantation; TNF-α: Tumor necrosis factor-alpha; IFN-γ: Interferon-gamma; IL: Interleukin.

Citation: Tüsüz Önata E, Özdemir Ö. Fecal microbiota transplantation in allergic diseases. World J Methodol 2025; 15(2): 101430
URL: https://www.wjgnet.com/2222-0682/full/v15/i2/101430.htm
DOI: https://dx.doi.org/10.5662/wjm.v15.i2.101430

Tüsüz Önata E, Özdemir Ö. Fecal microbiota transplantation in allergic diseases. World J Methodol 2025; 15(2): 101430 [PMID: 40548224 DOI: 10.5662/wjm.v15.i2.101430]

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