Looking into key bacterial proteins involved in gut dysbiosis

Table 2 Summary of secondary key proteins

Classification	Name	Function	Ref.
Flagellin		Inducing the secretion of proinflammatory cytokines.	[87]
Flagellin		Recuiting flagellin specific CD4+ T-cells.	[85]
Flagellin		Inducing the secretion of flagellin antibodies.	[88,89]
Flagellin		Inducing the secretion of AMPs.	[90]
Flagellin		Inducing the secretion of human β-defensin 2.	[91]
Flagellin		Inducing the expression of lncRNA (HIF1A-AS2) and suppressing NF-kB signaling pathway activation.	[92]
Outer membrane protein	OmpC, OmpW	Adhesion and invasion of the CD-associated Escherichia coli in intestinal epithelial cells. Cross-reactive bacterial proteins.	[95-97]
Outer membrane protein	FomA	Inducing upregulation of CD86, MHC II, and primary B cells. Inducing secretion of antigen-specific antibody IgA and IgG.	[99,100]
Bacterial division protein	FtsZ	Cross-reacting with TBB-5 and mediating the secretion of p-ANCA.	[102,103]
Bacterial heat shock protein	GroEL	Cross-reacting with Hsp60 and inducing antibodies.	[110,111]

p-ANCA: Perinuclear antineutrophil cytoplasmic antibody.