Tocilizumab as treatment for COVID-19: A systematic review and meta-analysis

Table 2 Laboratory and radiological characteristics of patients treated with tocilizumab

Ref.	Fever (baseline) °C/%	O2 sat. %	Cough %	Dyspnea %	Leucocytes 109/L	Lymphocites/Neutrophil 109/L	PLT 109/L	Hb g/dL	LDH	Liver tests IU/L	CRP mg/L	PCT ng/L	D-dimer	IL6 ng/L	Imaging %
Alattar et al[11], 2020	38/92	-	84	72	6.0	0.9/5.0	208	-	-	46/30	95.2	0.38	-	-	Infiltrates and ground glass opacities 100
Alberici et al[12], 2020	-/-	-	-	-	-	-/-	-	-	-	-	-	-	-	-	-
Capra et al[13], 2020	38/-	-	-	-	-	-/-	-	-	-	-	123	0.6	-	-	Bilateral pulmonary opacities 100
Colaneri et al[14], 2020	-/-	-	-	-	-	0.6/8.4	303	-	445	38/72	21.3	0.24	-	-	Interstitial lung disease 100
Hassoun et al[15], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Klopfenstein et al[16], 2020	-/-	90	-	-	-	0.67/-	-	-	-	-/-	158	-	-	-	≥ 50% lung involvement 60
Luo et al[17], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	96	-	-	71	-
Quartuccio et al[18], 2020	-/-	-	-	-	5540	0.68/4.5	157	-	625	-/-	79.05	-	835	63.5	-
Sciascia et al[19], 2020	< 38/39.7	-	-	-	-	-	-	-	-	-	-	-	-	-	Bilateral pulmonary infiltrates
Toniati et al[20], 2020	> 37.5/85	-	55	73	6	0.78	177	13.6	413	55/39	97	-	525	41	Ground glass opacities and consolidation, bilateral pulmonary infiltration
Xu et al[21], 2019	-/100	-	66.7	-	6.3	0.97	170	-	370	31/29	75	0.33	0.8	153	Ground glass opacities and focal consolidation, peripheral and subpleural
Ramaswamy et al[22], 2020	-/-	-	-	-	-	1.1/6.7	200	-	-	60/43.5	15.9	2.2	2900	371	-
Rimland et al[23], 2020	-/-	-	-	-	8.5	-/0.8	230	-	1203	51/35	197.3	-	343.5	30.65	-
Sanchez-Montalva et al[24], 2020	37.7/91.5	94	86.6	65.9	9.2	0.86/	199	13.3	446	53/41	17.98	-	295	74.8	-
Wadud et al[25], 2020	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Campochiaro et al[26], 2020	37.6/-	-	-	-	-	-/-	-	-	469	-/-	156	-	-	-	-
Morena et al[27], 2020	74.5/-	-	62.7	54.9	9.1	0.8/7.3	230	-	470	48/39	189	-	1706	116	Bilateral pulmonary opacities 100
Kimmig et al[28], 2020	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Roumier et al[29], 2020	-	-	-	-	-	-	-	-	-	-	189	-	3712	-	-
Ip et al[30], 2020	80	-	78	80	-	-/-	-	-	-	-/-	-	-		-	-
Perrone et al[31], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	30	-	-	-	-
Perez-Tanoira et al[32], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Somers et al[33], 2020	-/-	-	-	-	12.1	0.9/-	-	-	627	50/76	185	-	2400	-	-
Heili-Frades et al[34], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Issa et al[35], 2020	-/100	-	-	-	-	-/-	-	-	-	-/-	246	-	1354	-	Ground glass opacities
Garcia et al[36], 2020	-/98.7	-	83	43	-	0.87/-	-	-	-	-/-	97	-	918	-	-
Ayerbe et al[37], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Borku Uysal et al[38], 2020	-/92	92	100	67	6.1	1.09/4.3	180	13.8	259	33/39	54	-	599	-	Ground glass opacities
Fernandez-Cruz et al[39], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Garibaldi et al[40], 2020	-/-	-	-	-	-	-/-	-	-	-	-/-	-	-	-	-	-
Martínez-Sanz et al[41], 2020	36.8/-	91	-	-	-	0.89/5.4	-	-	669	-/32	113	-	809	70	-
Petrak et al[42], 2020	-	-	-	-	-	-	-	-	538	-	53.3	-	1.3	-	-
Rossi et al[43], 2020	37.5/-	94	-	-	-	1.128/-	-	-	-	-	168	-	-	-	-

-: Not available; PLT: Platelets; Hb: Hemoglobin; CRP: C reactive protein; PCT: Procalcitonin C; IL-6: Interleukin-6; sat: Saturation; LDH: Lactate dehydrogenase.