Epidemiological burden of parents being the index cases of COVID-19 infected children

Table 3 Subgroup wise weighted prevalence of parent being the index case in coronavirus disease 2019 infected children

Prevalence of COVID-19 infected children with parents being the index case
Subgroup	Category	Number of studies	Number of COVID-19 positive children	Number of COVID-19 positive children with parent being the index case	Weighted prevalence of COVID-19 positive children with parent being the index case		95% prediction interval	Heterogeneity measures
					%	95%CI		I2 (%)	Q (P value)
Continent	Asia	8	28	20	75.0	0.45-0.97	0.1-1.0	31.8	0.17
	Europe	2	583	324	58.0	0.52-0.63	Inestimable	-	-
	North America	1	2	0	0.0	0.00-0.84	Inestimable	-	-
	South America	2	9	2	11.0	0.00- 0.47	Inestimable	-	-
Country	21 European nations except France1	1	582	324	56.0	0.52-0.60	Inestimable	-	-
	France	1	1	0	0.0	0.00-0.98	Inestimable	-	-
	Brazil	1	2	2	100.0	0.16-1.00	Inestimable	-	-
	Chile	1	7	0	0.0	0.00-0.41	Inestimable	-	-
	China	3	11	9	87.0	0.54-1.00	Inestimable	-	-
	Iraq	1	3	3	100.0	0.29-1.00	Inestimable	-	-
	Singapore	1	9	7	78.0	0.40-0.97	Inestimable	-	-
	South Korea	2	4	1	18.0	0.00-0.77	Inestimable	-	-
	Taiwan	1	1	0	0.0	0.00-0.98	Inestimable	-	-
	United States	1	2	0	0.0	0.00-0.84	Inestimable	-	-
COVID-19 diagnosis in children	RT-PCR	12	620	344	50.0	0.24-0.76	0.0-1.0	63.4	0
	Rapid Method	1	2	2	100.0	0.16-1.00	Inestimable	-	-
COVID-19 diagnosis in the index case	RT-PCR	10	36	21	60.0	0.20-0.94	0.0-1.0	69.0	0.00
	History	1	582	324	56.0	0.52-0.60	Inestimable	-	-
	Unclear	2	4	1	18.0	0.00-0.77	Inestimable	-	-
COVID-19 index patient clinical presentation	Symptomatic	8	20	14	73.0	0.33-1.00	0.0-1.0	44.2	0.08
	Unclear	5	602	332	36.0	0.06-0.72	0.0-1.0	77.2	0.00
COVID-19 index patient mortality	Died	1	1	0	0.0	0.00-0.98	Inestimable	-	-
	Not died	6	17	12	74.0	0.29-1.00	0.0-1.0	48.5	0.08
	Unclear	6	604	334	44.0	0.13-0.78	0.0-1.0	74.1	0.00
Overall	NA	13	622	346	54.0	0.29-0.79	0.0-1.0	62.3	0.00

¹Austria, Belgium, Bulgaria, Croatia, Denmark, Estonia, Germany, Greece, Hungary, Ireland, Italy, Lithuania, Norway, Portugal, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, and the United Kingdom. RT-PCR: Reverse transcription polymerase chain reaction; NA: Not applicable; COVID-19: Coronavirus disease 2019.