High-potency sucralfate prevents and rapidly reverses chemo-radiation mucositis in a patient with stage 4b head and neck cancer

Table 3 Modified naranjo probability of intervention-caused response

	Questions	Yes	No	Don’t know	Case report
1	Are there previous conclusive reports on this response?	1	0	0	0 don’t know
2	Did the response appear after the intervention was administered?	2	-1	0	+2 Yes
3	Did the response disappear when the intervention was discontinued?	+1	0	0	+1 Yes
4	Did the response reappear when the intervention was re-administered?	+2	-1	0	+2 Yes
5	Are there alternative causes that could on their own have caused the reaction?	-1	+2	0	+2 No
6	Did the reaction reappear when a placebo was given?	-1	+1	0	+1 No
7	Was the intervention detected in the blood in concentrations known to be toxic?	+1	0	0	0 No
8	Was the response more apparent when the dose was increased, or less apparent when the dose was decreased?	+1	0	0	0 No
9	Did the patient have a similar response to the same or similar intervention in any previous exposure?	+1	0	0	+1 Yes
10	Was the response confirmed by any objective evidence?	+1	0	0	+1 Yes
Patients total score					10