Prognostic biomarkers for pancreatic ductal adenocarcinoma: A contemporary systematic review and modelling study

doi:10.5528/wjtm.126295

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World Journal of Translational Medicine

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2220-6132

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transl Med. Nov 28, 2026; 12(4): 126295
Published online Nov 28, 2026. doi: 10.5528/wjtm.126295

Table 4 Comparison of prognostic performance between the initial biologically derived signature and the least absolute shrinkage and selection operator-derived 5-gene signature in The Cancer Genome Atlas pancreatic adenocarcinoma cohort

Prognostic model	Cox model	Hazard ratio	P value	Harrell’s C-index	95%CI
Initial biologically derived signature	Univariable	1.13	0.239	0.522	0.472-0.579
Initial biologically derived signature	Multivariable	1.08	0.480	0.563	0.498-0.626
LASSO-derived 5-gene signature	Univariable	6.41	< 0.001	0.587	0.526-0.634
LASSO-derived 5-gene signature	Multivariable	6.13	< 0.001	0.599	0.534-0.653

CI: Confidence interval; LASSO: Least absolute shrinkage and selection operator.

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Citation: Tarara V, Panteris E, Varlamis S, Andreadou E, Pessach I, Bobos M, Chatzidimitriou M, Mitka S, Papoutsi A, Eleftheriou P, Skepastianos P, Karamitrousis E. Prognostic biomarkers for pancreatic ductal adenocarcinoma: A contemporary systematic review and modelling study. World J Transl Med 2026; 12(4): 126295
URL: https://www.wjgnet.com/2220-6132/full/v12/i4/126295.htm
DOI: https://dx.doi.org/10.5528/wjtm.126295

Tarara V, Panteris E, Varlamis S, Andreadou E, Pessach I, Bobos M, Chatzidimitriou M, Mitka S, Papoutsi A, Eleftheriou P, Skepastianos P, Karamitrousis E. Prognostic biomarkers for pancreatic ductal adenocarcinoma: A contemporary systematic review and modelling study. World J Transl Med 2026; 12(4): 126295 [DOI: 10.5528/wjtm.126295]

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