Possible roles of short-chain fatty acids in the pathophysiology and treatment of irritable bowel syndrome

doi:10.5528/wjtm.122740

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World Journal of Translational Medicine

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2220-6132

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transl Med. Sep 28, 2026; 12(3): 122740
Published online Sep 28, 2026. doi: 10.5528/wjtm.122740

Table 1 The proportion of the 3 main short chain fatty acids in irritable bowel syndrome patients that received 60 g of the donor’s transplant

SCFAs	Baseline	1 month after FMF	1 year after FMT	2 years after FMT	3 years after FMT
Acetic acid	64	59	60	51	50
Propionic acid	19	18	18	16	17
Butyric acid	17	23	22	33	33

SCFA: Short chain fatty acids; FMT: Fecal microbiota transplantation.

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Citation: El-Salhy M, Shin CM, Kim YS, Hatlebakk JG. Possible roles of short-chain fatty acids in the pathophysiology and treatment of irritable bowel syndrome. World J Transl Med 2026; 12(3): 122740
URL: https://www.wjgnet.com/2220-6132/full/v12/i3/122740.htm
DOI: https://dx.doi.org/10.5528/wjtm.122740

El-Salhy M, Shin CM, Kim YS, Hatlebakk JG. Possible roles of short-chain fatty acids in the pathophysiology and treatment of irritable bowel syndrome. World J Transl Med 2026; 12(3): 122740 [DOI: 10.5528/wjtm.122740]

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