Antiplatelet therapy in pulmonary embolism: Mechanisms and evidence

doi:10.5528/wjtm.121879

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World Journal of Translational Medicine

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2220-6132

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transl Med. Sep 28, 2026; 12(3): 121879
Published online Sep 28, 2026. doi: 10.5528/wjtm.121879

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Figure 1 Platelet-mediated immunothrombosis and the role of antiplatelet therapy in pulmonary embolism. C3a: Complement component 3a; C5a: Complement component 5a; NET: Neutrophil extracellular trap; P2Y12: Platelet purinergic P2Y12 receptor; PE: Pulmonary embolism; PSGL-1: P-selectin glycoprotein ligand 1; RBCs: Red blood cells; Xa: Activated coagulation factor X.

Citation: Kalamara TV, Dodos K, Georgakopoulou VE. Antiplatelet therapy in pulmonary embolism: Mechanisms and evidence. World J Transl Med 2026; 12(3): 121879
URL: https://www.wjgnet.com/2220-6132/full/v12/i3/121879.htm
DOI: https://dx.doi.org/10.5528/wjtm.121879

Kalamara TV, Dodos K, Georgakopoulou VE. Antiplatelet therapy in pulmonary embolism: Mechanisms and evidence. World J Transl Med 2026; 12(3): 121879 [DOI: 10.5528/wjtm.121879]

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