Beyond assumptions: Revisiting the link between consanguinity and pediatric neurodevelopmental disorders

doi:10.5528/wjtm.122602

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World Journal of Translational Medicine

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2220-6132

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transl Med. Jul 28, 2026; 12(2): 122602
Published online Jul 28, 2026. doi: 10.5528/wjtm.122602

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Figure 2 Conceptual model explaining variability in neurodevelopmental outcomes associated with consanguinity. This figure expands on the basic genetic pathway by incorporating modifying factors, including gene penetrance, involvement of specific developmental pathways, degree of consanguinity, and environmental influences. It illustrates how these factors contribute to heterogeneous clinical outcomes and may affect the detectability of associations in clinical studies.

Citation: Al-Beltagi M. Beyond assumptions: Revisiting the link between consanguinity and pediatric neurodevelopmental disorders. World J Transl Med 2026; 12(2): 122602
URL: https://www.wjgnet.com/2220-6132/full/v12/i2/122602.htm
DOI: https://dx.doi.org/10.5528/wjtm.122602

Al-Beltagi M. Beyond assumptions: Revisiting the link between consanguinity and pediatric neurodevelopmental disorders. World J Transl Med 2026; 12(2): 122602 [DOI: 10.5528/wjtm.122602]

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