Pericytes synthesize renin

Figure 1 Immunostaining for renin (brown) showing the overall distribution at low magnification in wild type and angiotensinogen deficient mice during embryonic (E18, A and H) and postnatal life (P1, P5, P10, P21, P45 and P70, B-G and I-N). A: Renin expression in large arteries and arterioles and in pericytes (arrowheads); B: Renin expression in large arteries, arterioles and in the glomerular mesangium; C: Renin expression is still extended in arterioles beyond the juxtaglomerular areas (JGAs); D: Renin expression is mostly restricted to the JGAs; E: Renin expression in JGAs and occasionally in few pericytes (arrowheads); F and G: Renin expression in JGAs; H: Renin expression in large arteries and arterioles and in pericytes (arrowheads) similar to A; I: Renin expression in large arteries and arterioles similar to B; J, L: Renin expression in thickened arteries, arterioles, pericytes (arrowheads) and tubules (arrows); M, N: Renin expression in thickened arteries and arterioles and in fewer pericytes (arrowheads). WT: Wild type; AGT: Angiotensinogen deficient. Bars: 100 μm.