Paediatric renal tumors: An insight into molecular characteristics, histomorphology and syndromic association

Table 2 Immunohistochemistry of paediatric renal tumors

Renal tumor	Immunohistochemistry expression
Paediatric cystic nephroma	ER positive[16]
Metanephric adenoma	WT1 and CD57 positive[24]
Metanephric stromal tumor	CD34 positive[29,31]
Metanephric adenofibroma	CD34 positive[33]
Ossifying renal tumor of infancy	EMA and Vimentin positive [38]
Nephroblastoma (Wilms tumor)	The blastemal component is WT1 and PAX8 positive; the epithelial component is cytokeratin and Epithelial Membrane Antigen and positive; stromal component is vimentin positive[2]
Malignant rhabdoid tumor of the kidney	SMARCB1/INI1 loss[64]
Clear cell sarcoma of the kidney	Cyclin D1 and BCOR positive[73]
Renal Ewing sarcoma	CD99 and NKX2-2 positive[87-88]
Renal cell carcinoma with MiT translocations	TFE3 positive[92]
ALK-rearranged renal cell carcinomas	ALK positive, INI1/SMARCB1 retained[97]
Eosinophilic solid and cystic renal cell carcinoma	CK20 and PAX8 positive whereas CK7 and C-kit negative[105]
SMARCB1-deficient renal medullary carcinoma	PAX8, Epithelial Membrane Antigen and vimentin positive [110]; SMARCB1/INI1 loss[111]