Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Nov 6, 2016; 5(6): 524-530
Published online Nov 6, 2016. doi: 10.5527/wjn.v5.i6.524
Factors associating with oxygenation of lower-limb muscle tissue in hemodialysis patients
Haruhisa Miyazawa, Susumu Ookawara, Kiyonori Ito, Katsunori Yanai, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Yuichiro Ueda, Yoshio Kaku, Keiji Hirai, Taro Hoshino, Kaoru Tabei, Yoshiyuki Morishita
Haruhisa Miyazawa, Susumu Ookawara, Kiyonori Ito, Katsunori Yanai, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Yuichiro Ueda, Yoshio Kaku, Keiji Hirai, Taro Hoshino, Yoshiyuki Morishita, Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Kaoru Tabei, Department of Internal Medicine, Minami-uonuma City Hospital, Niigata 949-6680, Japan
Author contributions: Miyazawa H and Ookawara S contributed to data acquisition, data analysis and interpretation, and writing of article; Miyazawa H, Ookawara S and Ito K contributed to study conception and design; Yanai K, Ishii H, Kitano T, Shindo M, Ueda Y, Kaku Y, Hirai K, Hoshino T, Tabei K and Morishita Y contributed to editing, reviewing and final approval of article.
Institutional review board statement: This study was reviewed and approved by Saitama Medical Center, Jichi Medical University (Saitama, Japan).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors report no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Susumu Ookawara, MD, PhD, Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-City, Saitama 330-8503, Japan. ookawaras@.jichi.ac.jp
Telephone: +81-48-6472111 Fax: +81-48-6476831
Received: June 27, 2016
Peer-review started: June 29, 2016
First decision: August 5, 2016
Revised: August 26, 2016
Accepted: September 7, 2016
Article in press: September 8, 2016
Published online: November 6, 2016
Core Tip

Core tip: Sarcopenia, defined by reduced muscle mass and peripheral arterial disease, is common in patients undergoing hemodialysis (HD). Therefore, muscle status, including muscle oxygenation, would deteriorate; however, no muscle status evaluation method has been established and remains under debate. Here we investigated the tissue oxygenation of lower-limb muscles using near-infrared spectroscopy in HD patients. Values of regional saturation of oxygen in the lower-limb muscles were significantly lower in HD patients than in healthy controls and independently associated with serum inorganic phosphate and albumin concentrations, both of which represent nutritional status.