Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2022; 11(2): 73-85
Published online Mar 25, 2022. doi: 10.5527/wjn.v11.i2.73
Renal biopsy reports in nephritic syndrome: Update
Saeed Taheri
Saeed Taheri, Department of Medicine, New Lahijan Scientific Foundation, Lahijan 44158-13166, Iran
Author contributions: Taheri S performed the literature review, meta-analyses, and report preparation.
Conflict-of-interest statement: None.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Saeed Taheri, MD, Doctor, Department of Medicine, New Lahijan Scientific Foundation, Hasheminejad Str, Lahijan 44158-13166, Iran. taherimd@gmail.com
Received: December 7, 2021
Peer-review started: December 7, 2021
First decision: January 25, 2022
Revised: January 31, 2022
Accepted: March 23, 2022
Article in press: March 23, 2022
Published online: March 25, 2022
ARTICLE HIGHLIGHTS
Research background

Nephritic syndrome (NiS) is a major indicator of severe kidney disease requiring renal biopsy for histopathological evaluation, but limited understanding of the syndrome and its significance is currently lacking due to the lack of a comprehensive review in the literature.

Research motivation

The current understanding on the epidemiology of renal diseases finally diagnosed in patients representing various clinical syndromes as indications for the renal biopsy is inaccurate and skewed.

Research objectives

This systematic review aims at collecting the available data in the literature to give the most possible comprehensive overview on the epidemiology of diagnoses that we may expect from the evaluations of renal biopsies in patients with nephritic syndrome.

Research methods

A systematic review of the literature has been conducted, with 47 studies identified for meta-analyses.

Research results

A myriad of results have been made through this systematic review, the most important of them is the high prevalence of immunoglobulin A nephropathy (about 38%) as the final diagnosis of nephritic syndrome, and diagnosing minimal change disease in a proportion of pediatric patients representing with NiS.

Research conclusions

The diagnostic spectrum of nephritic syndrome is quite wide, and clinicians should have a better overview on all the possibilities.

Research perspectives

It has clinical, research and health care perspectives to the society.