Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 6, 2016; 5(5): 448-454
Published online Sep 6, 2016. doi: 10.5527/wjn.v5.i5.448
Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?
Elizabeth Oei, Klara Paudel, Annemarie Visser, Hazel Finney, Stanley L Fan
Elizabeth Oei, Klara Paudel, Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London E1 1BB, United Kingdom
Annemarie Visser, Department of Nutrition and Dietetics, Barts Health NHS Trust, London E1 1BB, United Kingdom
Hazel Finney, Department of Clinical Biochemistry, Barts Health NHS Trust, London E1 1 BB, United Kingdom
Author contributions: Oei E and Fan SL designed the study, generated the tables and co-wrote the manuscript; Paudel K, Visser A and Finney H contributed to data collection and writing of the manuscript.
Institutional review board statement: The study (Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?) was conducted in accordance with the principles set out by the local ethical committee according to United Kingdom National Health Service audit and clinical service development.
Informed consent statement: The study (is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?) was conducted in accordance with the principles set out by the local ethical committee according to United Kingdom National Health Service audit and clinical service development. Patient consent is not required for data to be included in an audit and clinical service development (Quality Assurance) assessment.
Conflict-of-interest statement: The authors have declared no conflict-of-interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London E1 1BB, United Kingdom. s.fan@qmul.ac.uk
Telephone: +44-20-35942674 Fax: +44-20-35942691
Received: March 17, 2016
Peer-review started: March 18, 2016
First decision: April 18, 2016
Revised: May 2, 2016
Accepted: July 11, 2016
Article in press: July 13, 2016
Published online: September 6, 2016
Processing time: 168 Days and 12.2 Hours
Abstract
AIM

To study the relationship between overhydration (OH) in peritoneal dialysis (PD) patients and cardiac mortality.

METHODS

OH, as measured by body composition monitor (BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T (cTnT) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cTnT. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cTnT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH (> +2L). The Fresenius Body Composition Monitor was used to obtain hydration parameters. cTnT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.

RESULTS

There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage (10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement (2.95 L vs 1.35 L, P < 0.05). The mean (standard error of the means) hydration status of the 336 patients was +1.15 (0.12) L and the median [interquartile range (IQR)] cTnT level was 43.5 (20-90) ng/L. The cTnT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log (cTnT) with the OH value (Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median (IQR) hydration at baseline was +2.7 (2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cTnT levels (Spearman r value 0.29, P < 0.02).

CONCLUSION

Patients that were overhydrated had higher cTnT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cTnT.

Keywords: Bioimpedance; Fluid status; Peritoneal dialysis; Mortality; Overhydration; Cardiac troponin

Core tip: Overhydration measured by bioimpedance spectroscopy is an independent predictor of death in peritoneal dialysis patients. Most studies on this topic provide only a single baseline bioimpedance assessment. We present longitudinal data showing increased cardiac mortality in overhydrated patients, and significant correlation of overhydration with cardiac troponin-T (cTnT) levels. Over 6 mo, these patients had a mean of 7.4 body composition monitor readings and 3.4 cTnT assessments. Patients whose hydration status improved showed a corresponding improvement in cTnT. While observational studies cannot define causality, our results show overhydration is associated with cardiac mortality, and suggest overhydration may be a reversible risk factor.