Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response

Figure 2 Prion-exposed ovine PrP transgenic Drosophila show enhanced locomotor defect. Drosophila with pan neuronal expression of ovine VRQ(cyt) were fed VRQ/VRQ scrapie-free (blue circles, blue line) or scrapie-infected (red circles, red line) sheep brain homogenate at the larval stage of development. The locomotor activity of adult flies was assessed by a negative geotaxis climbing assay. The performance index is shown for each genotype of fly per time point (Reproduced with permission, from Thackray et al[100] 2014. © the Biochemical Society).