Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Infected cell protein 0 functional domains and their coordination in herpes simplex virus replication
Haidong Gu, Department of Biological Sciences, Wayne State University, Detroit, MI 48202, United States
Author contributions: Gu H wrote the paper.
Supported by National Institute of Allergy and Infectious Diseases, No. 1R01AI118992.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Haidong Gu, PhD, Assistant Professor, Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, United States. haidong.gu@wayne.edu
Telephone: +1-313-5776402
Received: August 29, 2015
Peer-review started: September 7, 2015
First decision: October 8, 2015
Revised: October 28, 2015
Accepted: December 4, 2015
Article in press: December 8, 2015
Published online: February 12, 2016
Peer-review started: September 7, 2015
First decision: October 8, 2015
Revised: October 28, 2015
Accepted: December 4, 2015
Article in press: December 8, 2015
Published online: February 12, 2016
Core Tip
Core tip: Due to the genomic limitation, viruses often use multifunctional proteins to ensure viral replication. Coordination of the multiple viral functions is critical for a successful viral infection. Infected cell protein 0 (ICP0) is notoriously multi-functional in terms of simultaneously targeting many host machineries located in different cellular compartments. Understanding the molecular basis of ICP0 multifunctionality is important for not only the elucidation of herpes simplex virus pathogenicity but also the delineation of host defense mechanisms.