Complement-mediated renal diseases after kidney transplantation - current diagnostic and therapeutic options in de novo and recurrent diseases

Figure 2 Renal histology in individuals with dense deposit disease. A: Light microscopy with silver stain showing a membranoproliferative glomerulonephritis pattern with double contours of the glomerular basement membrane; B: Immunofluorescence; C: Immunohistochemistry with immunoperoxidase showing strong capillary wall staining of C3 and some granular mesangial C3; D: Characteristic sausage-like, intramembranous, osmiophilic deposits on electron microscopy. Adapted from Barbour et al[11].